Lack of cortisone inhibition of chromosomal puffing inDrosophila melanogaster

Résumé L'administration de cortisone (ou d'hydrocortisone) à des larvesDrosophila n'inhibe pas le bourgeonnement normal des chromosomes de leurs glandes salivaires. Toutefois, la quantité de cortisone que ces larves peuvent tolérer est environ 1/10 de celle qui supprime le bourgeonnement chez les larvesSciara.     

多频率设计的试验解析综合法

本文针对机械系统动态设计的需要,从动力修改原理出发,导出了一种多阶固有频率的动态修改方法。本方法只需给出试验模态分析结果就可以完成所需全部计算。     

基于对应分析的冗余模糊C均值聚类算法研究

针对模糊C均值聚类（FCM）算法聚类原型最适合于球状类型簇的特点,提出了基于类间分离度和类内紧缩度加权的冗余聚类中心的FCM算法,即先将大簇或者延伸形状的簇（非凸）采用加权FCM算法分割成多个小类（冗余类）,从而规避FCM算法对初始聚类中心敏感的弱点．由于隶属度划分矩阵的元素是每个样本隶属于各冗余类的隶属度值,因此将其作为各冗余类的类特征,通过对应分析得到冗余类的新特征,再次采用加权FCM算法进行冗余类合并,最后达到分类效果．以代表曲线分割和曲面分割分类问题的3个典型数据集为算例,结果表明该方法能够识别不规则的簇,解决了FCM算法对初始聚类中心敏感的缺陷．     

高温交联酸用稠化剂合成及性能评价

利用丙烯酰胺(AM)与2-丙烯酰胺基-2-甲基丙磺酸(AMPS)作为原料,进行水溶液聚合,采用低温复合引发体系制备高温交联酸用稠化剂P(AM-co-AMPS),通过单因素分析法确定最佳反应条件;并对其纯化样品进行红外表征,室内性能评价。结果表明,该稠化剂酸溶性好,基液黏度随稠化剂加量增加而增大,配方:20%HCl+0.8%稠化剂+5%BZ酸化缓蚀剂+2%BZ措施用破乳助排剂+2%BZ酸化用铁离子稳定剂+0.3%BZ交联延迟剂。加入交联液(交联剂/交联延迟剂=1,交联比∶100∶0.8),90 s后能形成可挑挂冻胶,180℃,170 s~(-1)剪切速率下,剪切100 min,黏度保持在56 mPa·s左右。加入破胶剂后,在90℃加热1 h,破胶黏度为10 m Pa·s,利于酸液返排,可满足高温储层对交联酸的要求,具有较好的发展前景。     

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

The innate immune system senses viral infection by recognizing a variety of viral components (including double-stranded (ds)RNA) and triggers antiviral responses. The cytoplasmic helicase proteins RIG-I (retinoic-acid-inducible protein I, also known as Ddx58) and MDA5 (melanoma-differentiation-associated gene 5, also known as Ifih1 or Helicard) have been implicated in viral dsRNA recognition. In vitro studies suggest that both RIG-I and MDA5 detect RNA viruses and polyinosine-polycytidylic acid (poly(I:C)), a synthetic dsRNA analogue. Although a critical role for RIG-I in the recognition of several RNA viruses has been clarified, the functional role of MDA5 and the relationship between these dsRNA detectors in vivo are yet to be determined. Here we use mice deficient in MDA5 (MDA5-/-) to show that MDA5 and RIG-I recognize different types of dsRNAs: MDA5 recognizes poly(I:C), and RIG-I detects in vitro transcribed dsRNAs. RNA viruses are also differentially recognized by RIG-I and MDA5. We find that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical for picornavirus detection. Furthermore, RIG-I-/- and MDA5-/- mice are highly susceptible to infection with these respective RNA viruses compared to control mice. Together, our data show that RIG-I and MDA5 distinguish different RNA viruses and are critical for host antiviral responses.     

等时降线问题的求解

考虑了给定下降时间函数的下降曲线的求解问题.将质点沿光滑曲线从一定高度下滑所需时间的问题转化为积分方程求解的问题，并对积分方程进行阿贝尔积分变换，再利用积分换序方法给出了求解公式，最后证明了等时降线问题的解是一条倒摆线.     

Triple Medium Physical Model of Post Fracturing High-Rank Coal Reservoir in Southern Qinshui Basin

In this paper, influences on the reservoir permeability, the reservoir architecture and the fluid flow pattern caused by hydraulic fracturing are analyzed. Based on the structure and production fluid f...     

永磁同步电机速度伺服系统的分数阶内模控制

针对永磁同步电机(Permanent magnet synchronous motor,PMSM)速度伺服系统,提出了一种分数阶(Fractional order,FO)内模控制器设计方法。建立了PMSM速度伺服系统的简化数学模型,根据内模控制(Internal model control,IMC)原理,引入分数阶滤波器替代整数阶滤波器,推导出了一种分数阶内模控制器,该控制器仅包含两个可调参数,有效克服了分数阶PIλDμ控制器待整定参数较多的缺陷,并基于系统时域性能指标选择主导极点,给出了控制器参数的解析整定方法,避免了参数选择的盲目性。仿真结果表明,所提方法不仅可以使PMSM速度伺服系统具有较好的设定值跟踪和扰动抑制特性,而且对于系统参数摄动具有更好的鲁棒性。